No, these settings are not helpful to improve the performance of python code.
Please not that python, by default, is not the fastest language.
But there are ways to improve the speed.
For example you can use numpy, especially when working with arrays.
Also numexpr by be worth to have a look at.
Just to give you an indication of what is possible. Recently we improved the performance of one algorithm from taking 3:40 h to 5 minutes. This was mainly achieved by using numpy.