I am experiencing similar problems, except when I set the value of PYTHON_BIN using Ghanisen’s work around to C:…\Anaconda2\python.exe and click OK my environment settings are accepted, but when I try to run Sen2Cor I get an error telling me that PYTHON_BIN is not set. @Ghanisen Are there any other steps that weren’t detailed that allowed you to execute Sen2Cor successfully?