Error with OTB segmentation-meanshift

How to define the working directory for the OTB because at the time of execution it gave an error of working path is not defined?

I have checked the box many times in OTB_DIR and save it but reopen of the same external plugin gave an unchecked box to me.

How to define the bundle binaries for the OTB?

Please help me in the issues of OTB segmentation.