Hello,
calculating Statistics of a very large image (28842 x 106508) resulted in a negative number of pixels (#Pixels total). SNAP Version: 11.0.0
For further testing, I used one subimage with number of pixels < MAX_INT (28842 x 74456) and one with number of pixels > MAX_INT (28842 x 74457). Calculated Statistics for the first image was ok, for the second it was not ok.